Moderator: Andrew Patterson

Reputation:
180
Status:
Trusted
Location:
Penn State University
Website:
http://www.cmtc.psu.ed...
Twitter:
PSUmetabolomics
Scholar ID:
Google Scholar Page
Last seen:
1 year ago
Joined:
3 years, 3 months ago
Email:
a*****@psu.edu

At the Pennsylvania State University as part of the Center for Molecular Toxicology and Carcinogenesis, the Patterson lab is focused on understanding the host-metabolite-microbiome axis—specifically how the manipulation of gut bacteria through xenobiotic exposure impacts bile acid pools, their metabolism, and how they interact with host nuclear receptors. The lab employs a variety of cutting-edge tools, including 1H NMR- and mass spectrometry-based metabolomics, metagenomics/metatranscriptomics, and conventional and gnotobiotic genetically-modified mice to facilitate the study of these pathways and understand their impact on human health and disease.

Posts by Andrew Patterson

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Answer: A: How to implement a 'commerical' mass spectrometry data processing software on t
... hi Biswa I will pass this information on to Dr. Anton Nekrutenko here at Penn State. He has been interested in setting up more metabolomic workflows in Galaxy. You might also check biostars.org which has a lot of dedicated Galaxy discussions. Andrew ...
written 12 months ago by Andrew Patterson180
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Job: ASSISTANT PROFESSOR IN METABOLOMICS at Penn State University
... https://psu.jobs/job/62955 The Department of Veterinary and Biomedical Sciences in the College of Agricultural Sciences and the Huck Institutes of the Life Sciences of The Pennsylvania State University are seeking to hire a new tenure-track Assistant Professor. The successful candidate will have ex ...
job metabolomics metabolism academia professor written 13 months ago by Andrew Patterson180
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Answer: A: How would you define "epi-metabolome" ?
... By definition I guess any metabolite that is methylated, acetylated or phosphorylated could be part of the epi-metabolome. However, is the community ready for another "omics" word? If you think yes, read more here. ...
written 20 months ago by Andrew Patterson180
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Answer: A: Ultra-high resolution MS techniques
... There has been a lot of great work using FTMS by the Jones group from Emory University. However I'm not convinced high resolution mass spectrometry alone is enough to convincingly demonstrate that a metabolite has been identified.  You can read here or here.  ...
written 20 months ago by Andrew Patterson180
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Answer: A: Does meta-metabolome exists and are people exploring ?
... There's a great paper from the Siuzdak lab comparing conventional and germ free mice. Convincingly they demonstrate some metabolites are generated from the gut microbiota.  I don't know of any resources specifically cataloging these host and bacteria metabolites, but the gut microbiota organ can no ...
written 20 months ago by Andrew Patterson180
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Tool: Interesting new concept---crowd sourcing metabolite identification for metabolomics
... This is a super clever new concept in metabolite ID was developed at UCSD and the brain child of Dr. Peter Dorrestein. Its a great idea and I'm looking forward to seeing what problems it can help solve. We're working on getting some data up there now.   https://www.youtube.com/watch?v=5lBDvD4pzDA ...
tool metabolite id written 20 months ago by Andrew Patterson180 • updated 20 months ago by Istvan Albert ♦♦ 90
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Forum: My love/hate relationship with databases
... I recall starting out with my first metabolomics study---how does the cellular metabolome change in response to ionizing radiation (IR). In this study we exposed cells to different doses of IR, extracted the metabolites (more on this in another post), and then analyzed them on a Waters UHPLC system ...
forum metabolomics analysis tool database written 20 months ago by Andrew Patterson180
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Tutorial: Metabolomics Training Online Resource
... Exciting new resource for metabolomics training. Check it out here---http://metabolomicsinmedicine.org ...
tutorial analysis written 21 months ago by Andrew Patterson180
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Answer: A: Have metabolomic discoveries made it into the clinic?
... Here's a link to one of the original papers. It's a really cool technology (think metabolite sniffer on the end of the surgeon's knife) and one I'm sure will find application in all sorts of surgery.  ...
written 2.2 years ago by Andrew Patterson180
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Answer: A: How to improve Metastars?
... Thanks, we'll start posting some protocols soon. In fact, I'd love to get feedback if you try them.  ...
written 2.2 years ago by Andrew Patterson180

Latest awards to Andrew Patterson

Scholar 2.2 years ago, created an answer that has been accepted. For A: For metabolomics data sets (where, samples <<< metabolites) out of several class
Autobiographer 3.0 years ago, has more than 80 characters in the information field of the user's profile.

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