Question: Have metabolomic discoveries made it into the clinic?
1
gravatar for Andrew Patterson
2.6 years ago by
Penn State University
Andrew Patterson180 wrote:

I was recently asked if I could describe any metabolomic discoveries that have made it into the clinic. It could be that metabolomics identified a biomarker for disease or metabolomics was instrumental in identifying a new drug or drug target. You could answer this question quickly by rattling off a few inborn errors of metabolism tests or show results from your recent cholesterol screen. Indeed these tests are using small molecules to identify/predict disease and fit nicely with what metabolomics is all about --- identifying chemical fingerprints left behind by biological processes. 

However for the sake of argument, let's say that the biomarker or drug had to come from a study where the word "metabolomics" or something similar (e.g., open metabolite profiling, metabonomics, etc) was used. 

The first that comes to mind is sarcosine as biomarker of prostate cancer. When I was a postdoctoral fellow, this study got me excited about the potential of metabolomics and I think might be the first example of a small molecule biomarker identified from a metabolomics study that is now a clinical test. Metabolon in general has made remarkable progress in advancing their metabolomic discoveries into the clinic. 

My guess is that as we start focusing more on this concept of precision medicine, clinical labs will begin to add more comprehensive panels to their standard tests. Metabolomic discoveries, perhaps from efforts like the Imperial College Phenome Center, will help drive bench-to-bedside metabolomics as they start to understand how to apply these approaches at the population level. 

What other discoveries are out there? What do you think are the hurdles? Please post and contribute to the discussion.

ADD COMMENTlink modified 23 months ago by isaac.gerg0 • written 2.6 years ago by Andrew Patterson180
1
gravatar for Paul Benton
2.4 years ago by
Paul Benton10
United States
Paul Benton10 wrote:

We've just finished the MSACL conference here in San Diego which is asking just this question. I think there was a lot of promising research which was discussed and presented. The two that come directly to mind as an answer to clinical relevance of metabolomics is the iKnift and the various bacterial detection systems. There are many more exciting examples that came out of the conference in terms of biomarkers but I think these two are the one that will hit the clinic first as biomarker studies always have more work that needs to be done.

ADD COMMENTlink written 2.4 years ago by Paul Benton10
0
gravatar for Andrew Patterson
2.3 years ago by
Penn State University
Andrew Patterson180 wrote:

Here's a link to one of the original papers. It's a really cool technology (think metabolite sniffer on the end of the surgeon's knife) and one I'm sure will find application in all sorts of surgery. 

ADD COMMENTlink written 2.3 years ago by Andrew Patterson180
0
gravatar for isaac.gerg
23 months ago by
isaac.gerg0
United States
isaac.gerg0 wrote:

Pending its scientific validity, the tests Genova labs offers are used in the clinic, especially in nautropathic settings.Lord has published several peer reviewed papers and wrote a book on the use of those tests.  The Genova TRIAD is an especially popular tests that ND's and nutritionists use on patients.  

https://www.gdx.net/product/triad-bloodspot-profile-metabolic-nutritional-test-blood-spot

https://www.gdx.net/product/metabolic-analysis-test-organic-acids-urine

My question back to the community is if these tests have been peer reviewed, why arent they used more in MD and DO's offices?

ADD COMMENTlink modified 23 months ago • written 23 months ago by isaac.gerg0
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